On a still summer night in Amsterdam’s old quarter, Pia de Jong gives birth to a delicate, bright-eyed baby girl with a riddle on her back―a pale blue spot that soon multiplies. Soon, a doctor reveals the devastating answer: it is a rare and deadly form of leukemia, often treated with chemotherapy, a cure nearly as dangerous to a newborn as the disease itself. Pia and her husband Robbert decide not to subject Charlotte to chemotherapy. Instead, they transform their canal house into a sanctuary where Charlotte can live surrounded by love, where Pia can give her a chance to live. In return, Charlotte gives her mother the greatest gift of all: purpose.